Journal: International Journal of Molecular Sciences
Article Title: Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness
doi: 10.3390/ijms24076769
Figure Lengend Snippet: Topography of EEG microstructure during distinct states of unconsciousness. The group probability density distributions (PDE)/30 min of the relative amplitudes of all conventional EEG frequency bands (delta, theta, sigma, beta, and gamma) in the motor cortex (MCx) compared with the hippocampus (Hipp). PDE data for each brain structure and each state of unconsciousness are pooled from all rats belonging to the corresponding experimental group (NREM sleep: MCx n = 12 and Hipp n = 13; ketamine/diazepam anesthesia: MCx n = 6 and Hipp n = 7; propofol anesthesia: MCx: n = 6 and Hipp n = 7). Arrows show the statistically significantly higher (up arrows) or lower (down arrows) amplitude of a particular EEG frequency band in the hippocampus compared with the motor cortex at p ≤ 0.05.
Article Snippet: To analyze the EEG amplitude differences during NREM sleep (physiological unconsciousness) and each anesthesia (different states of unconsciousness induced by anesthetics with different mechanisms of action), we calculated the group probability density distributions of the relative amplitudes over 30 min of NREM sleep or distinct anesthesia using the probability density estimation (PDE) routine provided by MATLAB R2011a [ , , , , ].
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